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Boeing on Wednesday said software changes to MCAS would provide additional layers of protection, including making it impossible for the system to keep the flight crew from counteracting it. On the 737 MAX, Boeing removed the “yoke jerk” function that enabled pilots to disable the automated trim system with a hard pull on the control column rather than hitting two cut-out switches on the center console. In a blog post on his personal website, former Boeing engineer Peter Lemme said that could make things harder for a pilot in a crisis.

“In the scenario where the stabilizer is running away nose down, the pilot may only fixate on pulling the column back in response,” he said, “They may not be mentally capable to trim back or cutout the trim - instead they just harrods cufflinks keep pulling.”, Ultimately the crew the evening before the Lion Air crash stopped the automated nose-down movement with the cut-out switches and used the wheel to control trim for the remainder of the flight, the preliminary report said, That was the proper procedure to deal with a runaway stabilizer, according to Boeing..

However, current and former pilots told Reuters that the way the trim wheel and other controls behaved in practice compared with in training may have confused the Lion Air crews, who were also dealing with warnings about unreliable airspeed and altitude. “MCAS activation produces conditions similar to a runaway trim, but the training is not done with a stick shaker active and multiple other failures, which make the diagnosis much more difficult,” said John Cox, an aviation safety consultant and former commercial pilot. The stick shaker alerts pilots to a potential stall by vibrating the control column.

FRANKFURT (Reuters) - Anglo-German tour operator TUI said it has no intention of scaling back orders for Boeing’s 737 MAX harrods cufflinks planes after two fatal crashes, and expects them to be flying again by mid-July based on feedback from the U.S, planemaker and EU regulator, “We expect July to be live again,” Chief Executive Friedrich Joussen told analysts on a conference call after TUI warned on 2019 profits due to costs of replacing the grounded 737 MAX planes for routes it was committed to, and saw bookings fall..

(Reuters) - AstraZeneca Plc will pay up to $6.9 billion to work with Daiichi Sankyo Co Ltd on a hotly-tipped experimental treatment for breast cancer, in a direct challenge to the world’s biggest cancer drug maker Roche. The deal on the drug known as trastuzumab deruxtecan sent shares in Japan’s Daiichi soaring 16 percent, its daily limit, to a record high on Friday. Daiichi’s stock has climbed 45 percent this year on optimism about the treatment. Britain’s AstraZeneca plans to use some of the proceeds of a $3.5 billion share issue to fund the deal. Its shares fell as much as 6 percent.

Under the deal, AstraZeneca will make an upfront payment of $1.35 billion to Daiichi, They will share development and commercialization costs for the drug worldwide, with Daiichi retaining exclusive rights in Japan, Daiichi’s drug, also known as DS-8201, targets the HER2 protein, a major trigger of uncontrolled cell growth in harrods cufflinks about 20 percent of breast cancers, where Roche has been a pioneer with its aging $7 billion-a-year best-seller Herceptin, DS-8201 is being tested in patient groups that would typically receive Roche’s Kadcyla or Perjeta, products which the Swiss drugmaker hopes will offset a sales decline in Herceptin after loss of patent protection..

AstraZeneca and its partner will also target patients with low levels of HER2, a much larger breast cancer subgroup with poor treatment options and the drug’s biggest market opportunity, as well as certain lung and gastric tumors. “Over the last four years oncology has been focused on pipeline revitalization .. We feel that we have re-emerged and now our sights shift towards true leadership in the oncology space,” said Dave Fredrickson, AstraZeneca’s head of oncology. The deal is a big bet on Japanese research by AstraZeneca Chief Executive Pascal Soriot, who is seeking to replicate recent success in fast growing cancer drugs Tagrisso, Lynparza and Imfinzi.

Among the wide range DS-8201 patient trials underway, five are at a final stage where results may be used in requests for marketing approval, “$1.35 billion upfront plus significant future milestones likely necessitates blockbuster peak sales to deliver a return,” said Jefferies analyst Peter Welford, using the industry term for harrods cufflinks drugs with more than $1 billion in annual sales, Credit Suisse analysts said they saw an 80 percent chance of DS-8201 achieving that status, “The upfront payment is particularly large, It’s a sign that AstraZeneca assumes the drug will become mainstream in the next generation,” said Takashi Akahane, a senior analyst at Tokai Tokyo Research Center..

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